Spatial distribution of physiologic 12-lead QRS complex (2024)

Hnatkova, K., Andršová, I., Toman, O., Smetana, P., Huster, K. M., Šišáková, M., Barthel, P., Novotný, T., Schmidt, G., & Malik, M. (2021). Spatial distribution of physiologic 12-lead QRS complex. Scientific Reports, 11(1), Article 4289. https://doi.org/10.1038/s41598-021-83378-8

Hnatkova, Katerina ; Andršová, Irena ; Toman, Ondřej et al. / Spatial distribution of physiologic 12-lead QRS complex. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

@article{85067f195ca24eb4862ab4731a315403,

title = "Spatial distribution of physiologic 12-lead QRS complex",

abstract = "The normal physiologic range of QRS complex duration spans between 80 and 125ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal values, a technology is proposed based on the singular value decomposition and on the separation of different orthogonal components of the QRS complex. This allows classification of the proportions of different components representing the 3-dimensional representation of the electrocardiographic signal as well as classification of components that go beyond the 3-dimensional representation and that correspond to the degree of intricate convolutions of the depolarisation sequence. The technology was applied to 382,019 individual 10-s ECG samples recorded in 639 healthy subjects (311 females and 328 males) aged 33.8 ± 9.4years. The analyses showed that QRS duration was mainly influenced by the proportions of the first two orthogonal components of the QRS complex. The first component demonstrated statistically significantly larger proportion of the total QRS power (expressed by the absolute area of the complex in all independent ECG leads) in females than in males (64.2 ± 11.6% vs 59.7 ± 11.9%, p < 0.00001—measured at resting heart rate of 60 beats per minute) while the second component demonstrated larger proportion of the QRS power in males compared to females (33.1 ± 11.9% vs 29.6 ± 11.4%, p < 0.001). The analysis also showed that the components attributable to localised depolarisation sequence abnormalities were significantly larger in males compared to females (2.85 ± 1.08% vs 2.42 ± 0.87%, p < 0.00001). In addition to the demonstration of the technology, the study concludes that the detailed convolution of the depolarisation waveform is individual, and that smoother and less intricate depolarisation propagation is the mechanism likely responsible for shorter QRS duration in females.",

author = "Katerina Hnatkova and Irena Andr{\v s}ov{\'a} and Ond{\v r}ej Toman and Peter Smetana and Huster, {Katharina M.} and Martina {\v S}i{\v s}{\'a}kov{\'a} and Petra Barthel and Tom{\'a}{\v s} Novotn{\'y} and Georg Schmidt and Marek Malik",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41598-021-83378-8",

language = "English",

volume = "11",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Hnatkova, K, Andršová, I, Toman, O, Smetana, P, Huster, KM, Šišáková, M, Barthel, P, Novotný, T, Schmidt, G & Malik, M 2021, 'Spatial distribution of physiologic 12-lead QRS complex', Scientific Reports, vol. 11, no. 1, 4289. https://doi.org/10.1038/s41598-021-83378-8

Spatial distribution of physiologic 12-lead QRS complex. / Hnatkova, Katerina; Andršová, Irena; Toman, Ondřej et al.
In: Scientific Reports, Vol. 11, No. 1, 4289, 12.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Spatial distribution of physiologic 12-lead QRS complex

AU - Hnatkova, Katerina

AU - Andršová, Irena

AU - Toman, Ondřej

AU - Smetana, Peter

AU - Huster, Katharina M.

AU - Šišáková, Martina

AU - Barthel, Petra

AU - Novotný, Tomáš

AU - Schmidt, Georg

AU - Malik, Marek

N1 - Publisher Copyright:© 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - The normal physiologic range of QRS complex duration spans between 80 and 125ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal values, a technology is proposed based on the singular value decomposition and on the separation of different orthogonal components of the QRS complex. This allows classification of the proportions of different components representing the 3-dimensional representation of the electrocardiographic signal as well as classification of components that go beyond the 3-dimensional representation and that correspond to the degree of intricate convolutions of the depolarisation sequence. The technology was applied to 382,019 individual 10-s ECG samples recorded in 639 healthy subjects (311 females and 328 males) aged 33.8 ± 9.4years. The analyses showed that QRS duration was mainly influenced by the proportions of the first two orthogonal components of the QRS complex. The first component demonstrated statistically significantly larger proportion of the total QRS power (expressed by the absolute area of the complex in all independent ECG leads) in females than in males (64.2 ± 11.6% vs 59.7 ± 11.9%, p < 0.00001—measured at resting heart rate of 60 beats per minute) while the second component demonstrated larger proportion of the QRS power in males compared to females (33.1 ± 11.9% vs 29.6 ± 11.4%, p < 0.001). The analysis also showed that the components attributable to localised depolarisation sequence abnormalities were significantly larger in males compared to females (2.85 ± 1.08% vs 2.42 ± 0.87%, p < 0.00001). In addition to the demonstration of the technology, the study concludes that the detailed convolution of the depolarisation waveform is individual, and that smoother and less intricate depolarisation propagation is the mechanism likely responsible for shorter QRS duration in females.

AB - The normal physiologic range of QRS complex duration spans between 80 and 125ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well as for the wide range of normal values, a technology is proposed based on the singular value decomposition and on the separation of different orthogonal components of the QRS complex. This allows classification of the proportions of different components representing the 3-dimensional representation of the electrocardiographic signal as well as classification of components that go beyond the 3-dimensional representation and that correspond to the degree of intricate convolutions of the depolarisation sequence. The technology was applied to 382,019 individual 10-s ECG samples recorded in 639 healthy subjects (311 females and 328 males) aged 33.8 ± 9.4years. The analyses showed that QRS duration was mainly influenced by the proportions of the first two orthogonal components of the QRS complex. The first component demonstrated statistically significantly larger proportion of the total QRS power (expressed by the absolute area of the complex in all independent ECG leads) in females than in males (64.2 ± 11.6% vs 59.7 ± 11.9%, p < 0.00001—measured at resting heart rate of 60 beats per minute) while the second component demonstrated larger proportion of the QRS power in males compared to females (33.1 ± 11.9% vs 29.6 ± 11.4%, p < 0.001). The analysis also showed that the components attributable to localised depolarisation sequence abnormalities were significantly larger in males compared to females (2.85 ± 1.08% vs 2.42 ± 0.87%, p < 0.00001). In addition to the demonstration of the technology, the study concludes that the detailed convolution of the depolarisation waveform is individual, and that smoother and less intricate depolarisation propagation is the mechanism likely responsible for shorter QRS duration in females.

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U2 - 10.1038/s41598-021-83378-8

DO - 10.1038/s41598-021-83378-8

M3 - Article

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AN - SCOPUS:85101277787

SN - 2045-2322

VL - 11

JO - Scientific Reports

JF - Scientific Reports

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Hnatkova K, Andršová I, Toman O, Smetana P, Huster KM, Šišáková M et al. Spatial distribution of physiologic 12-lead QRS complex. Scientific Reports. 2021 Dec;11(1):4289. doi: 10.1038/s41598-021-83378-8